Trillian is coming out with a new version of their mashup-IM client (someday) called Astra. There's a little video about it on their site at trillian.cc and it's gorgeous. A friend of mine even gave me a copy of the beta, but I haven't had the guts to install it to try it out yet.
I bought into Trillain (gave them money) after I'd spent a few years using it. I do like it a lot. My only major gripe right now is that the GoogleIM broke. However, the newest version seems to have solved that... Also, I had to give them money to get JABBER to work (for Google.)
Didn't mind, though, I do love their client enough to want to support it.