DGNers in Science

[StormKnight (1)]

Propofol helps keep inflammation in check in the brain.

PubMed link

[Slogo]

Couldn't understand it but I respect the hell out of scientific pursuits.

[Troy Spiral (13)]

Propofol helps keep inflammation in check in the brain.

Propofol’s effects on phagocytosis, proliferation, nitrate production, and cytokine secretion in pressure-stimulated microglial cells

Guangxiang Yu MDa, *,>>> Michael Dymond MD- aka Storm Knight. <<< a, b, c, *, Lisi Yuan PhDb, Lakshmi S. Chaturvedi PhDa, c, Hiroe Shiratsuchi PhDc, Srinivasan Durairaj PhDb, H. Michael Marsh MBBSa, c and Marc D. Basson MD, PhD, MBAa, b, c,

The money shot of that abstract:

(In the context of intracrainal effects of Traumatic Brain Injury)

To elucidate the effect of increased intracranial pressure on microglial function, we studied the effects of increased extracellular pressure on primary human microglial cell phagocytosis, proliferation, cytokine secretion, and total nitrate production.

Had to look up

1. microglial cell phagocytosis, 2. proliferation, 3. cytokine secretion, and 4.total nitrate production.

Four differen't things before it made sense some kind of sense to me. Even just the term "cytokine" apparenlty has a pages long debate as to what type of cells it actually includes.

What "increased pressure" means I'm not totally sure, meaning I assume "added strain on these cells/systems" ?

So we have:

durring a traumatic brain injury:

"Strain" on the immune system (MIcroglial cell phagocytosis/proliferation), Strain (decreased? function?) of the nervous system regulatory cells (Cytokine) and the body's ability to (via nitrates) a whole host of stuff such as blood clotting / anti infection / blood flow. (?) I following that?

And thus Propofol's (Seditive , similar to Ativan / Valium but given in liquid form?) effect, and I assume positive effects on these strains?

Sounds like I need me some Propofol rather than this dang vallium. I think they gave it to me in the ER once (anxiety attack, post traumatic brain injury), that was good stuff, asked for it again later but they said it wasn't something they could give me to take as-needed. Damnit.

Wish there were inject able versions of all my meds honestly, then I wouldn't have to deal with the stomach issues that some of them cause / they'd all be faster acting. (maybe less side effects too? I some cases since that'd bypass my digestive system).

Even having just spent an hour reading I'm still a little foggy on JUST THE EXTRACT. hah.

[StormKnight (1)]

Propofol is used for induction of general anesthesia, or an ICU sedation. It isn't narcotic based or a benzodiazepine like vailum.

Basically what happens, someone gets a traumatic brain injury (TBI) the pressure in the brain case increases, causing brain damage. The damage control cells (migcroglia cells,) under pressure will release chemicals meant to bring in cells to help control damage, but also cause inflammation, increasing pressure. This causes a vicious circle that continues to increase pressure, worsening the brain injury.

Propofol stops the cells from releasing the chemicals, keeping most of the inflammation chemicals in check, but allows cells to come in to take care of the damage. We have seen in in cells when the underlying membrane is stretched or it is put under pressure (strained.)

[Glory13666]

Propofol is the drug that killed Micheal Jackson. It's surprising to think that it would be used for ICU sedation though because it has a short half life and has to be given often. I don't know to much about it but I'm pretty sure it's only given IV or at least I've never heard of it being given any other way. I doubt it could replace your Ativan. lol.

[StormKnight (1)]

It is usually given as a drip, titrated to keep them at a certain responsiveness level. It can be used as the sole anesthesia agent, also as a drip, for those who can't handle the gases.

For inducing anesthesia, it is given as a bolus to get one off to sleep quickly, and give the anesthesiologist time to get the breathing tube in, get the patient on a ventilator, and turn on the agent that will keep them asleep for the rest of the case. A bolus will last about 15 minutes.

I discussed this in the MJ tragedy here.

[KatRN05]

Propofol is the drug that killed Micheal Jackson. It's surprising to think that it would be used for ICU sedation though because it has a short half life and has to be given often. I don't know to much about it but I'm pretty sure it's only given IV or at least I've never heard of it being given any other way. I doubt it could replace your Ativan. lol.

Propofol is safe when used properly i.e. when a patient is intubated and mechanically ventilated. Doctors like it because of the short half-life. It wears off quickly when the drip is stopped and it will quickly sedate the patient when resumed. We use this a lot of TBI patients so we can easily assess their mental status.

As far as Michael Jackson goes, the dumbfuck had no business taking this or asking for this to be administered.

[Troy Spiral (13)]

When reading this stuff, part of the problem is the medical articles tend to be heavy on jargon in a way that say, physics papers , don't seem to be QUITE so heavy on I'm not sure if that is just because I'm more familiar with physical science terms and I'm just biased toward other sciences or if that is a real phenomenon. (I've had nurses (two specifically, one that I had as an inpatient and one that I know from DGN) tell me doctors go out of their way to speak over their heads when its unnecessary, not sure how widespread that is, seem very counterproductive / unlikely to me.)

I actually spent several hours looking it Propofol up, apparently it doesn't exist in any other form. Seems odd to me, unless maybe the side effects of extended use are rough. (more rough than some of the existing prescription sedatives) Unless maybe something to do with the chemical compound makes it difficult to have in a non-liquid lower-strength form.

But in terms of this paper, SK , the key finding or focus is the "TBI usefulness" right? So as to maybe suggest that this be used more , or indicated more often , specifically for TBI patients (at the time of the inflammation caused by the TBI) than it might otherwise be currently.

[taysteewonderbunny]

Congrats on the publication, SK. So nice to see you have second listing in authors. WTG!

[StormKnight (1)]

Actually, I'm one of the two primary authors. The asterisk after our names should link to the phase "G.Y. and M.D. contributed equally to this article."

We did a coin toss when we did who was going to be first with that in mind.

[Raev]

[Simon Bar Sinister]

congrats, StormKnight!!!

:peanutbutterjellytime: